The effect of posture on hypertension induced by sympathomimetic amines in man.
نویسندگان
چکیده
After atropine the hypertension induced by Arterenol in man is abolished by tilting to the vertical position. This does not occur with equipressor doses of Arterenol or with atropine alone. Arterenol and atropine in combination could not be shown to have a blocking action at sympathetic ganglions in animal experiments, nor was there blockade of the carotid sinus reflex pathways. The failure to maintain Arterenol-induced hypertension after atropine was thus unexplained. Further experiments on the clinical implications of this phenomenon were performed. IN PREVIOUS studies' on the effect of atropine in increasing the pressor response to Arterenol (norepinephrine) in man, we found in one subject that the headache associated with the hypertension disappeared on rising from the supine to the erect position. On determining the blood pressure after the subject stood up it was found to have fallen from 190/110 mm. Hg to 70/50. On reclining the previous high level of pressure was found to have returned. The phenomena associated with the pressor effect of Arterenol are of interest because of the presence of this amine in the adrenal medulla2 and in epinephrine preparations of natural origin.3 Arterenol has also been considered by Goldenberg and co-workers' as a possible mediator in essential hypertension. The present studies were performed to find out how consistently the postural depressor response occurred, and to study its mechanism.
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عنوان ژورنال:
- Circulation
دوره 5 3 شماره
صفحات -
تاریخ انتشار 1952